In Vitro Evaluation of a Peptide-Mesoporous Silica Nanoparticle Drug Release System against HIV-1
It has been shown that the optimized VIR-576 derivative of the natural HIV-1 entry inhibitor targeting the viral gp41 fusion peptide is safe and effective in infected individuals.However, high doses of this peptide were required, and stability, as well as delivery, must be improved for clinical application.Here, we examined the loading and release